BDBM435243 N-(tert-butyl)-5-(5-methylpyridin-3- yl)-8-(((trans)-2- phenylcyclopropanecarboxamido) methyl)-3,4-dihydroisoquinoline-2(1H)- carboxamide (mixture of 2 isomers)::US10568876, Example 8

SMILES Cc1cncc(c1)-c1ccc(CNC(=O)C2C[C@H]2c2ccccc2)c2CN(CCc12)C(=O)NC(C)(C)C

InChI Key InChIKey=SLQLJXBXTBSYED-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 435243   

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM435243(US10568876, Example 8 | N-(tert-butyl)-5-(5-methyl...)
Affinity DataIC50: 82.3nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
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