BDBM435242 US10568876, Example 21::US10568876, Example 7::methyl 3-(2-(tert-butylcarbamoyl)-8- ((2-(3-methyl-1,2,4-oxadiazol-5- yl)cyclopropanecarboxamido)methyl)- 1,2,3,4-tetrahydroisoquinolin-5- yl)benzoate (mixture of 4 isomers)

SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CC2c2nc(C)no2)c2CN(CCc12)C(=O)NC(C)(C)C

InChI Key InChIKey=YAVMOTIZADXZGP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 435242   

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM435242(methyl 3-(2-(tert-butylcarbamoyl)-8- ((2-(3-methyl...)
Affinity DataIC50: 15.5nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
Go to US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM435242(methyl 3-(2-(tert-butylcarbamoyl)-8- ((2-(3-methyl...)
Affinity DataIC50: 15.5nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
Go to US Patent