BDBM4352 (2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoic acid::benzylidenemalononitrile (BMN) deriv. 36

SMILES OC(=O)C(=C\c1ccc(O)c(O)c1)\C#N

InChI Key InChIKey=CJMWBHLWSMKFSM-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 4352   

TargetEpidermal growth factor receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM4352((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoic a...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of EGFR in human A431 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 1(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM4352((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoic a...)
Affinity DataIC50: 3.33E+5nMAssay Description:Inhibition of human recombinant Tdp1 assessed as conversion of 14-mer 5'-32P-labeled 3'-phosphotyrosyl DNA substrate N14Y to 14-mer 5'-32P-labeled 3'...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM4352((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoic a...)
Affinity DataKi:  2.50E+4nM IC50: 7.00E+4nMAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2005
Entry Details Article
PubMed