BDBM434870 7-{8,9,15-triazatetracyclo[16.3.1.12,6.18,11]tetracosa-1(22),2,4,6(24),9,11::US10577383, Example 30

SMILES Nc1cc(C2CCNCCc3cccc(c3)-c3cccc(Cn4cc2cn4)c3)c2nn[nH]c2n1

InChI Key InChIKey=YWRGWLPPHNREOZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 434870   

TargetMyeloperoxidase(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM434870(US10577383, Example 30 | 7-{8,9,15-triazatetracycl...)
Affinity DataIC50: 550nMAssay Description:MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen Cat. #A12222) which can...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
Go to US Patent

TargetMyeloperoxidase(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM434870(US10577383, Example 30 | 7-{8,9,15-triazatetracycl...)
Affinity DataIC50: 50nMAssay Description:MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen Cat. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
Go to US Patent

TargetMyeloperoxidase(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM434870(US10577383, Example 30 | 7-{8,9,15-triazatetracycl...)
Affinity DataIC50: 21nMAssay Description:Inhibition of MPO (unknown origin) chlorination activity incubated for 10 mins followed by NaCl addition by aminophenyl fluorescein assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed