BDBM434537 US10562900, Example 15

SMILES COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(cc4)N4CCN(C)CC4)n[nH]c3c2)c1Cl

InChI Key InChIKey=RBMWCFYMBVLYGJ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 434537   

TargetVascular endothelial growth factor receptor 2(Human)
Shanghai Haihe Pharmaceutical

US Patent
LigandPNGBDBM434537(US10562900, Example 15)
Affinity DataIC50: 200nMAssay Description:The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1(Human)
Shanghai Haihe Pharmaceutical

US Patent
LigandPNGBDBM434537(US10562900, Example 15)
Affinity DataIC50: 100nMAssay Description:The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Shanghai Haihe Pharmaceutical

US Patent
LigandPNGBDBM434537(US10562900, Example 15)
Affinity DataIC50: 100nMAssay Description:The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Shanghai Haihe Pharmaceutical

US Patent
LigandPNGBDBM434537(US10562900, Example 15)
Affinity DataIC50: 100nMAssay Description:The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1(Human)
Shanghai Haihe Pharmaceutical

US Patent
LigandPNGBDBM434537(US10562900, Example 15)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of recombinant human FGFR1 using poly (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Shanghai Haihe Pharmaceutical

US Patent
LigandPNGBDBM434537(US10562900, Example 15)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of recombinant human FGFR1 using poly (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed