BDBM434315 US10562891, Example 235::US11008308, Example 235

SMILES c1c(cc(c2c1N=C(NC2=O)CSC3CCC(CC3)O)F)OCC4CC4

InChI Key InChIKey=NKZDEFKPZSLQRF-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 434315   

TargetProtein mono-ADP-ribosyltransferase PARP14 [1611-1801](Human)
Ribon Therapeutics

US Patent
LigandPNGBDBM434315(US10562891, Example 235 | US11008308, Example 235)
Affinity DataIC50: 1.00E+3nMAssay Description:Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetProtein mono-ADP-ribosyltransferase PARP14(Human)
Ribon Therapeutics

US Patent
LigandPNGBDBM434315(US10562891, Example 235 | US11008308, Example 235)
Affinity DataIC50: 1.00E+3nMAssay Description:Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetProtein mono-ADP-ribosyltransferase PARP14(Human)
Ribon Therapeutics

US Patent
LigandPNGBDBM434315(US10562891, Example 235 | US11008308, Example 235)
Affinity DataIC50: 3nMAssay Description:Displacement of a biotinylated small molecule probe from human PARP14 catalytic domain incubated for 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetProtein mono-ADP-ribosyltransferase PARP14(Human)
Ribon Therapeutics

US Patent
LigandPNGBDBM434315(US10562891, Example 235 | US11008308, Example 235)
Affinity DataIC50: 3nMAssay Description:Inhibition of PARP14 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetProtein mono-ADP-ribosyltransferase PARP14(Human)
Ribon Therapeutics

US Patent
LigandPNGBDBM434315(US10562891, Example 235 | US11008308, Example 235)
Affinity DataIC50: 3nMAssay Description:Inhibition of human PARP14 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details Article
PubMedPDB3D3D Structure (crystal)