BDBM434025 1-(4-(1H-pyrazol-4- yl)phenyl)-4-(3- fluoro-5- methoxybenzyl)-3- (hydroxymethyl)-1H- 1,2,4-triazol-5(4H)- one::US10562887, Example 144

SMILES COc1cc(F)cc(Cn2c(CO)nn(-c3ccc(cc3)-c3cn[nH]c3)c2=O)c1

InChI Key InChIKey=UQEVZCIHTWIWBW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 434025   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM434025(1-(4-(1H-pyrazol-4- yl)phenyl)-4-(3- fluoro-5- met...)
Affinity DataIC50: 5nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
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