BDBM433968 2-(4-(1H-pyrazol- 4-yl)phenyl)-4-(2- fluorobenzyl)-5- methyl-2,4- dihydro-3H-1,2,4- triazol-3-one::US10562887, Example 87

SMILES Cc1nn(-c2ccc(cc2)-c2cn[nH]c2)c(=O)n1Cc1ccccc1F

InChI Key InChIKey=TVEXEFORWMKWFZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 433968   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM433968(2-(4-(1H-pyrazol- 4-yl)phenyl)-4-(2- fluorobenzyl)...)
Affinity DataIC50: 27.5nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
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