BDBM433961 1-(4-(1H-pyrazol- 4-yl)phenyl)-4-(3- methoxybenzyl)-3- methyl-1H-1,2,4- triazol-5(4H)-one::US10562887, Example 80

SMILES COc1cccc(Cn2c(C)nn(-c3ccc(cc3)-c3cn[nH]c3)c2=O)c1

InChI Key InChIKey=YGAKKQXKODMRED-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 433961   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM433961(1-(4-(1H-pyrazol- 4-yl)phenyl)-4-(3- methoxybenzyl...)
Affinity DataIC50: 5nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent