BDBM433929 1-(4-(1H- pyrazol- 4-yl)phenyl)- 4-(1-(3- methoxy- phenyl)ethyl)-::US10562887, Example 47::US10562887, Example 48

SMILES COc1cccc(c1)C(C)n1cnn(-c2ccc(cc2)-c2cn[nH]c2)c1=O

InChI Key InChIKey=ZPRULOVTMAUUBU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 433929   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM433929(US10562887, Example 48 | 1-(4-(1H- pyrazol- 4-yl)p...)
Affinity DataIC50: 27.5nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM433929(US10562887, Example 48 | 1-(4-(1H- pyrazol- 4-yl)p...)
Affinity DataIC50: 5nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent