BDBM433926 4-(3,5-difluoro- benzyl)-1-(3- ethyl-4-(1H- pyrazol-4- yl)phenyl)-1H- 1,2,4-triazol- 5(4H)-one::US10562887, Example 44

SMILES CCc1cc(ccc1-c1cn[nH]c1)-n1ncn(Cc2cc(F)cc(F)c2)c1=O

InChI Key InChIKey=VKOZKKQJFASAIA-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 433926   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM433926(4-(3,5-difluoro- benzyl)-1-(3- ethyl-4-(1H- pyrazo...)
Affinity DataIC50: 27.5nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
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