BDBM433759 4-(3-fluoro- 5-methoxy- benzyl)-1-(3- methoxy-4- (1H-pyrazol- 4-yl)phenyl)- 1H-1,2,4- triazol-5(4H)-::US10562887, Example 26

SMILES COc1cc(F)cc(Cn2cnn(-c3ccc(-c4cn[nH]c4)c(OC)c3)c2=O)c1

InChI Key InChIKey=KFBKJFRUZTVCKN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 433759   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM433759(US10562887, Example 26 | 4-(3-fluoro- 5-methoxy- b...)
Affinity DataIC50: 5nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent