BDBM433740 1-(4-(1H- pyrazol-4- yl)phenyl)-4- (3-fluoro-5- methoxy- benzyl)-1H- 1,2,4-triazol- 5(4H)-one::US10562887, Example 21

SMILES COc1cc(F)cc(Cn2cnn(-c3ccc(cc3)-c3cn[nH]c3)c2=O)c1

InChI Key InChIKey=XIMNLMJGPYGCKS-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 433740   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM433740(US10562887, Example 21 | 1-(4-(1H- pyrazol-4- yl)p...)
Affinity DataIC50: 5nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
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