BDBM433702 1-(4-(1H- pyrazol-4- yl)phenyl)-4- (3-methoxy- benzyl)-1H- 1,2,4-triazol-::US10562887, Example 18

SMILES COc1cccc(Cn2cnn(-c3ccc(cc3)-c3cn[nH]c3)c2=O)c1

InChI Key InChIKey=RORQYKTXFQRTGG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 433702   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM433702(US10562887, Example 18 | 1-(4-(1H- pyrazol-4- yl)p...)
Affinity DataIC50: 5nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM433702(US10562887, Example 18 | 1-(4-(1H- pyrazol-4- yl)p...)
Affinity DataIC50: 5nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed