BDBM433624 4-(3-methoxy- 4-(1H-pyrazol- 4-yl)phenyl)-1- (3-methoxy- benzyl)-1H- 1,2,4-triazol- 5(4H)-one::US10562887, Example 6

SMILES COc1cccc(Cn2ncn(-c3ccc(-c4cn[nH]c4)c(OC)c3)c2=O)c1

InChI Key InChIKey=XMDQPPLKVRAOLU-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 433624   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM433624(US10562887, Example 6 | 4-(3-methoxy- 4-(1H-pyrazo...)
Affinity DataIC50: 27.5nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
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