BDBM433503 US10562853, Compound 21

SMILES Cc1ccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)nc1

InChI Key InChIKey=LMUCVWASWOAHCM-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 433503   

Target5-hydroxytryptamine receptor 1A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM433503(US10562853, Compound 21)
Affinity DataKi:  3.80nMAssay Description:Displacement of [3H]8-OH-DPAT from recombinant human 5HT1A receptor stably expressed in CHO-K1 cell membranes measured after 60 mins by microbeta2 sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM433503(US10562853, Compound 21)
Affinity DataKi:  52nMAssay Description:5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM433503(US10562853, Compound 21)
Affinity DataKi: <1.00E+3nMAssay Description:Displacement of [3H]-prazosin from alpha1 adrenergic receptor in rat cortex measured after 30 mins by microbeta2 scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Neurolixis

US Patent
LigandPNGBDBM433503(US10562853, Compound 21)
Affinity DataKi: >1.00E+3nMAssay Description:D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetAlpha-1A adrenergic receptor(Human)
Neurolixis

US Patent
LigandPNGBDBM433503(US10562853, Compound 21)
Affinity DataKi: >1.00E+3nMAssay Description:Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetD(2) dopamine receptor(Human)
Neurolixis

US Patent
LigandPNGBDBM433503(US10562853, Compound 21)
Affinity DataKi: <1.00E+3nMAssay Description:Displacement of [3H]-methylspiperone from recombinant human D2 receptor stably expressed in CHO-K1 cell membranes measured after 60 mins by microbeta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed