BDBM432300 US10577361, E10::US10577361, E9

SMILES Cc1ncoc1-c1nnc(SCCCN2CCO[C@@H](C2)c2ccc(cc2)C(F)(F)F)n1C

InChI Key InChIKey=OEUUCWVHNBAMPM-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 432300   

TargetD(3) dopamine receptor(Human)
Indivior

US Patent
LigandPNGBDBM432300(US10577361, E10 | US10577361, E9)
Affinity DataKi:  17.4nMAssay Description:[3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
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TargetD(3) dopamine receptor(Human)
Indivior

US Patent
LigandPNGBDBM432300(US10577361, E10 | US10577361, E9)
Affinity DataKi:  53.7nMAssay Description:[3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
Go to US Patent

TargetD(2) dopamine receptor(Human)
Indivior

US Patent
LigandPNGBDBM432300(US10577361, E10 | US10577361, E9)
Affinity DataKi:  2.29E+3nMAssay Description:CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to Gα16 protein (CHO-Gα16-hD2L) were seeded into b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
Go to US Patent

TargetD(2) dopamine receptor(Human)
Indivior

US Patent
LigandPNGBDBM432300(US10577361, E10 | US10577361, E9)
Affinity DataKi:  4.37E+3nMAssay Description:CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to Gα16 protein (CHO-Gα16-hD2L) were re-suspended ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
Go to US Patent

TargetD(2) dopamine receptor(Human)
Indivior

US Patent
LigandPNGBDBM432300(US10577361, E10 | US10577361, E9)
Affinity DataKi: >1.00E+4nMAssay Description:CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to Gα16 protein (CHO-Gα16-hD2L) were seeded into b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
Go to US Patent

TargetD(2) dopamine receptor(Human)
Indivior

US Patent
LigandPNGBDBM432300(US10577361, E10 | US10577361, E9)
Affinity DataKi:  1.17E+4nMAssay Description:CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to Gα16 protein (CHO-Gα16-hD2L) were re-suspended ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
Go to US Patent