BDBM43220 4-[3-(4-methoxyphenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]benzenesulfonamide::4-[5-(4-methoxyphenyl)-3-phenyl-2-pyrazolin-1-yl]benzenesulfonamide::4-[5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl]benzenesulfonamide::MLS000693334::SMR000299863::US9388139, 11::cid_2950007

SMILES COc1ccc(cc1)C1CC(=NN1c1ccc(cc1)S(N)(=O)=O)c1ccccc1

InChI Key InChIKey=QBNZBMVRFYREHK-UHFFFAOYSA-N

Data  3 IC50  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 43220   

LigandPNGBDBM43220(MLS000693334 | 4-[3-(4-methoxyphenyl)-5-phenyl-3,4...)
Affinity DataEC50:  8.04E+3nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2011
Entry Details
PCBioAssay
LigandPNGBDBM43220(MLS000693334 | 4-[3-(4-methoxyphenyl)-5-phenyl-3,4...)
Affinity DataEC50:  8.04E+3nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2011
Entry Details
PCBioAssay
TargetRas-related protein Rab-2A(Dog)
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM43220(MLS000693334 | 4-[3-(4-methoxyphenyl)-5-phenyl-3,4...)
Affinity DataEC50:  704nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2011
Entry Details
PCBioAssay
TargetRas-related protein Rab-2A(Dog)
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM43220(MLS000693334 | 4-[3-(4-methoxyphenyl)-5-phenyl-3,4...)
Affinity DataEC50:  704nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2011
Entry Details
PCBioAssay
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
German University

US Patent
LigandPNGBDBM43220(MLS000693334 | 4-[3-(4-methoxyphenyl)-5-phenyl-3,4...)
Affinity DataIC50: 3.80E+3nMAssay Description:PDE activity was measured using the IMAP fluorescence polarization assay (Molecular Devices) in which binding of hydrolyzed cyclic nucleotide substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2017
Entry Details
Go to US Patent

TargetProstaglandin G/H synthase 1(Human)
German University

US Patent
LigandPNGBDBM43220(MLS000693334 | 4-[3-(4-methoxyphenyl)-5-phenyl-3,4...)
Affinity DataIC50: 1.00E+5nMAssay Description:The activities of COX-1 and COX-2 were measured after the addition of arachidonic acid and incubation at 25° C. for 5 min by absorbance at 590 nm as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2017
Entry Details
Go to US Patent

TargetProstaglandin G/H synthase 2(Human)
German University

US Patent
LigandPNGBDBM43220(MLS000693334 | 4-[3-(4-methoxyphenyl)-5-phenyl-3,4...)
Affinity DataIC50: 1.00E+5nMAssay Description:The activities of COX-1 and COX-2 were measured after the addition of arachidonic acid and incubation at 25° C. for 5 min by absorbance at 590 nm as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2017
Entry Details
Go to US Patent

LigandPNGBDBM43220(MLS000693334 | 4-[3-(4-methoxyphenyl)-5-phenyl-3,4...)
Affinity DataEC50:  2.10E+3nMAssay Description:Inhibition of GST-tagged wildtype Cdc42 (unknown origin) incubated for 2 hrs in presence of BODIPY FL GTP by flow cytometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
LigandPNGBDBM43220(MLS000693334 | 4-[3-(4-methoxyphenyl)-5-phenyl-3,4...)
Affinity DataEC50:  1.40E+3nMAssay Description:Inhibition of GST-tagged wildtype Cdc42 (unknown origin) incubated for 2 hrs in presence of BODIPY FL GDP by flow cytometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed