BDBM4312 (2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(2,4-dimethoxyphenyl)prop-2-enamide::Tyrphostin deriv. 64

SMILES COc1ccc(NC(=O)C(=C\c2ccc(O)c(O)c2)\C#N)c(OC)c1

InChI Key InChIKey=CSHGVUBBAZPQSJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 4312   

TargetEpidermal growth factor receptor(Human)
Hebrew University of Jerusalem

LigandPNGBDBM4312((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(2,4-dimeth...)
Affinity DataIC50: 1.70E+3nMAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2005
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Hebrew University of Jerusalem

LigandPNGBDBM4312((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(2,4-dimeth...)
Affinity DataIC50: 2.51E+4nMAssay Description:Inhibitory activity against epidermal growth factor receptor (EGFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
University of Tennessee Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM4312((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(2,4-dimeth...)
Affinity DataIC50: 1.66E+5nMAssay Description:Inhibitory activity tested against protein kinase HER-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed