BDBM431067 6-[4-(3-[[(2S,4S)-4-Hydroxy-1-[6-oxo-5-(trifluoromethyl)-1,6-dihydropyridazin-4-yl]pyrrolidin-2-yl]methoxy]benzoyl)piperazin-1-yl]pyridine-3-carbonitrile::US10550105, Example 51::US10870641, Example 51::US11014913, Example 51

SMILES O[C@H]1C[C@@H](COc2cccc(c2)C(=O)N2CCN(CC2)c2ccc(cn2)C#N)N(C1)c1cn[nH]c(=O)c1C(F)(F)F

InChI Key InChIKey=CRVUUERXDVRKFW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 431067   

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Ribon Therapeutics

US Patent
LigandPNGBDBM431067(6-[4-(3-[[(2S,4S)-4-Hydroxy-1-[6-oxo-5-(trifluorom...)
Affinity DataIC50: 100nMAssay Description:Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
Go to US Patent

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Ribon Therapeutics

US Patent
LigandPNGBDBM431067(6-[4-(3-[[(2S,4S)-4-Hydroxy-1-[6-oxo-5-(trifluorom...)
Affinity DataIC50: 100nMAssay Description:Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2021
Entry Details
Go to US Patent

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Ribon Therapeutics

US Patent
LigandPNGBDBM431067(6-[4-(3-[[(2S,4S)-4-Hydroxy-1-[6-oxo-5-(trifluorom...)
Affinity DataIC50: 100nMAssay Description:Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
Go to US Patent