BDBM4309 Tyrphostin deriv. 58::ethyl 2-[(2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamido]-3-phenylpropanoate

SMILES CCOC(=O)C(Cc1ccccc1)NC(=O)C(=C\c1ccc(O)c(O)c1)\C#N

InChI Key InChIKey=IZNDRNBAQQZJSB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 4309   

TargetEpidermal growth factor receptor(Human)
Hebrew University of Jerusalem

LigandPNGBDBM4309(ethyl 2-[(2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-...)
Affinity DataIC50: 1.53E+3nMAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2005
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
University of Tennessee Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM4309(ethyl 2-[(2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-...)
Affinity DataIC50: 3.31E+5nMAssay Description:Inhibitory activity tested against protein kinase HER-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Hebrew University of Jerusalem

LigandPNGBDBM4309(ethyl 2-[(2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-...)
Affinity DataIC50: 4.90E+4nMAssay Description:Inhibitory activity against epidermal growth factor receptor (EGFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed