BDBM430732 (R)-(4-fluorophenyl)(8-methyl-3-(quinolin-2-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone::US10544150, Compound 115

SMILES C[C@H]1N(CCn2c1nnc2-c1ccc2ccccc2n1)C(=O)c1ccc(F)cc1

InChI Key InChIKey=YKPRLSIENHBXFV-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 430732   

TargetNeuromedin-K receptor(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM430732(US10544150, Compound 115 | (R)-(4-fluorophenyl)(8-...)
Affinity DataIC50: 260nMAssay Description:Antagonistic activity against NK3R (unknown origin) expressed in CHO cells assessed as inhibition of NKB-induced intracellular calcium flux by Calciu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM430732(US10544150, Compound 115 | (R)-(4-fluorophenyl)(8-...)
Affinity DataKi: <500nMAssay Description:The ability of the compounds of the invention to inhibit the binding of the NK-3 receptor selective antagonist SB222200 was assessed by an in vitro r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
Go to US Patent