BDBM430529 US10555944, Example 261::US10953005, Example 261

SMILES CCOc1cc(-c2ccc(nc2)N2CC3CC(C2)N3C(=O)[C@H](N(C)C)c2cccc(Cl)c2)c2c(cnn2c1)C#N

InChI Key InChIKey=XWZFATVRYIQRIY-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 430529   

LigandPNGBDBM430529(US10555944, Example 261 | US10953005, Example 261)
Affinity DataIC50: 30.7nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
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LigandPNGBDBM430529(US10555944, Example 261 | US10953005, Example 261)
Affinity DataIC50: 61.4nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
Go to US Patent

LigandPNGBDBM430529(US10555944, Example 261 | US10953005, Example 261)
Affinity DataIC50: 58.7nMAssay Description:The potency of a compound inhibiting G81 OR mutant RET kinase was determined using CisBio's HTRF Kinease-TK assay technology. The assays containe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM430529(US10555944, Example 261 | US10953005, Example 261)
Affinity DataIC50: 30.7nMAssay Description:RET: Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
Go to US Patent

LigandPNGBDBM430529(US10555944, Example 261 | US10953005, Example 261)
Affinity DataIC50: 61.4nMAssay Description:RET: Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
Go to US Patent

LigandPNGBDBM430529(US10555944, Example 261 | US10953005, Example 261)
Affinity DataIC50: 58.7nMAssay Description:RET G810R: The potency of a compound inhibiting G810R mutant RET kinase was determined using CisBio's HTRF Kinease-TK assay technology. The assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
Go to US Patent