BDBM430272 US10556883, Compound 11

SMILES Cc1cc(COc2ccc(cc2)S(=O)(=O)NC2(CC(=O)NO)CN(C2)C(=O)CC(C)(C)C)c2ccccc2n1

InChI Key InChIKey=VOUFFRPOAAEWMF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 430272   

TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Galderma Research & Development

US Patent
LigandPNGBDBM430272(US10556883, Compound 11)
Affinity DataIC50: 8.20nMAssay Description:Activity of the compounds was investigated using TACE (ADAM17) isolated enzyme. The screening of ADAM17 inhibitors was performed with a profluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
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TargetInterstitial collagenase(Human)
Galderma Research & Development

US Patent
LigandPNGBDBM430272(US10556883, Compound 11)
Affinity DataIC50: 1.00E+4nMAssay Description:The enzymatic reaction was performed in 384-well microplates with a final volume of 10 L containing 1% DMSO. Recombinant Human catalytic domains of M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
Go to US Patent