BDBM430271 US10556883, Compound 10

SMILES CN1CCN(CC1)C(=O)N1CC(CC(=O)NO)(C1)NS(=O)(=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1

InChI Key InChIKey=IJAPQSNDPHYWTL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 430271   

TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Galderma Research & Development

US Patent
LigandPNGBDBM430271(US10556883, Compound 10)
Affinity DataIC50: 2.80nMAssay Description:Activity of the compounds was investigated using TACE (ADAM17) isolated enzyme. The screening of ADAM17 inhibitors was performed with a profluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
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TargetInterstitial collagenase(Human)
Galderma Research & Development

US Patent
LigandPNGBDBM430271(US10556883, Compound 10)
Affinity DataIC50: 1.00E+4nMAssay Description:The enzymatic reaction was performed in 384-well microplates with a final volume of 10 L containing 1% DMSO. Recombinant Human catalytic domains of M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
Go to US Patent