BDBM4298 (2E)-3-(3,4-dihydroxyphenyl)-2-[(4-nitrophenyl)carbonyl]prop-2-enenitrile::Tyrphostin deriv. 33

SMILES Oc1ccc(\C=C(/C#N)C(=O)c2ccc(cc2)[N+]([O-])=O)cc1O

InChI Key InChIKey=WSDDCSPJUMHQSE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 4298   

TargetEpidermal growth factor receptor(Human)
Hebrew University of Jerusalem

LigandPNGBDBM4298((2E)-3-(3,4-dihydroxyphenyl)-2-[(4-nitrophenyl)car...)
Affinity DataIC50: 2.30E+3nMAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2005
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Hebrew University of Jerusalem

LigandPNGBDBM4298((2E)-3-(3,4-dihydroxyphenyl)-2-[(4-nitrophenyl)car...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of EGFR in human A431 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
University of Tennessee Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM4298((2E)-3-(3,4-dihydroxyphenyl)-2-[(4-nitrophenyl)car...)
Affinity DataIC50: 3.02E+3nMAssay Description:Inhibitory activity tested against protein kinase HER-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Hebrew University of Jerusalem

LigandPNGBDBM4298((2E)-3-(3,4-dihydroxyphenyl)-2-[(4-nitrophenyl)car...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibitory activity against epidermal growth factor receptor (EGFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed