BDBM429748 (R)-5-(3-(4- (3,4-dichloro-5- methoxyphenyl) piperidin-1- yl)-3-oxopropyl) imidazolidine-2,4- dione::US10550100, Compound 69

SMILES COc1cc(cc(Cl)c1Cl)C1CCN(CC1)C(=O)CC[C@H]1NC(=O)NC1=O

InChI Key InChIKey=FUVOMTJFSKUMQI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 429748   

LigandPNGBDBM429748(US10550100, Compound 69 | (R)-5-(3-(4- (3,4-dichlo...)
Affinity DataIC50: 75nMAssay Description:The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID NO: 2) by human ADAMTS-5.For the dose res...More data for this Ligand-Target Pair
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Date in BDB:
11/7/2020
Entry Details
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LigandPNGBDBM429748(US10550100, Compound 69 | (R)-5-(3-(4- (3,4-dichlo...)
Affinity DataIC50: 12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
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Date in BDB:
11/7/2020
Entry Details
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LigandPNGBDBM429748(US10550100, Compound 69 | (R)-5-(3-(4- (3,4-dichlo...)
Affinity DataIC50: 75nMAssay Description:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEMS INC...More data for this Ligand-Target Pair
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Date in BDB:
11/7/2020
Entry Details
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TargetCollagenase 3(Human)
Galapagos

US Patent
LigandPNGBDBM429748(US10550100, Compound 69 | (R)-5-(3-(4- (3,4-dichlo...)
Affinity DataIC50: 100nMAssay Description:The basis for the assay is the cleavage of the substrate 390 MMP FRET Substrate I (Anaspec Cat# AS-27076) by human MMP13 (Chemicon, Cat#CC068).For th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
Go to US Patent