BDBM429681 5-cyclopropyl- 5-(3-oxo-3-(4- phenylpiperidin- 1-yl)propyl) imidazolidine- 2,4-dione::US10550100, Compound 7

SMILES O=C(CCC1(NC(=O)NC1=O)C1CC1)N1CCC(CC1)c1ccccc1

InChI Key InChIKey=CGABQNPHDLBFSJ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 429681   

TargetADAMTS5(Rat)
Galapagos

US Patent
LigandPNGBDBM429681(US10550100, Compound 7 | 5-cyclopropyl- 5-(3-oxo-3...)
Affinity DataIC50: 75nMAssay Description:The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID NO: 2) by rnADAMTS-5 (1-564-6H).For the d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
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LigandPNGBDBM429681(US10550100, Compound 7 | 5-cyclopropyl- 5-(3-oxo-3...)
Affinity DataIC50: 75nMAssay Description:The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID NO: 2) by human ADAMTS-5.For the dose res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
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LigandPNGBDBM429681(US10550100, Compound 7 | 5-cyclopropyl- 5-(3-oxo-3...)
Affinity DataIC50: 100nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
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LigandPNGBDBM429681(US10550100, Compound 7 | 5-cyclopropyl- 5-(3-oxo-3...)
Affinity DataIC50: 100nMAssay Description:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEMS INC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
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TargetCollagenase 3(Human)
Galapagos

US Patent
LigandPNGBDBM429681(US10550100, Compound 7 | 5-cyclopropyl- 5-(3-oxo-3...)
Affinity DataIC50: 100nMAssay Description:The basis for the assay is the cleavage of the substrate 390 MMP FRET Substrate I (Anaspec Cat# AS-27076) by human MMP13 (Chemicon, Cat#CC068).For th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
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LigandPNGBDBM429681(US10550100, Compound 7 | 5-cyclopropyl- 5-(3-oxo-3...)
Affinity DataIC50: 109nMAssay Description:Inhibition of human recombinant ADAMTS-5 assessed as cleavage of fluorescent substrate using FAM-TBIS-1 by biochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed