BDBM429672 US10550091, No. LC-81::US10947203, No. LC-81

SMILES COc1ccc(Cl)cc1-c1ncc(C(=O)c2ccc(cc2)C(C)(C)C)n1C

InChI Key InChIKey=MCFOMWUDZBRXHH-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 429672   

TargetNuclear receptor subfamily 1 group I member 2(Human)
St. Jude Children''S Research Hospital

US Patent
LigandPNGBDBM429672(US10550091, No. LC-81 | US10947203, No. LC-81)
Affinity DataIC50: 6.40E+3nMAssay Description:The time-resolved fluorescence resonance transfer (TR-FRET) hPXR competitive binding assay was performed according to the manufacturer's instruct...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
Go to US Patent

TargetNuclear receptor subfamily 1 group I member 2(Human)
St. Jude Children''S Research Hospital

US Patent
LigandPNGBDBM429672(US10550091, No. LC-81 | US10947203, No. LC-81)
Affinity DataEC50:  1.20E+3nMAssay Description:The hPXR transactivation assays (PXR agonistic and antagonistic assays) were performed in the HepG2 cells stably expressing FLAG-hPXR and CYP3A4-luci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
Go to US Patent

TargetNuclear receptor subfamily 1 group I member 2(Human)
St. Jude Children''S Research Hospital

US Patent
LigandPNGBDBM429672(US10550091, No. LC-81 | US10947203, No. LC-81)
Affinity DataIC50: 6.40E+3nMAssay Description:The time-resolved fluorescence resonance transfer (TR-FRET) hPXR competitive binding assay was performed according to the manufacturer's instruct...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
Go to US Patent

TargetNuclear receptor subfamily 1 group I member 2(Human)
St. Jude Children''S Research Hospital

US Patent
LigandPNGBDBM429672(US10550091, No. LC-81 | US10947203, No. LC-81)
Affinity DataEC50:  1.20E+3nMAssay Description:The hPXR transactivation assays (PXR agonistic and antagonistic assays) were performed in the HepG2 cells stably expressing FLAG-hPXR and CYP3A4-luci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
Go to US Patent