BDBM429656 US10550091, No. LC-65::US10947203, No. LC-65

SMILES COc1ccc(C)cc1-n1nnc(c1CCl)S(=O)(=O)c1ccc(cc1)C(C)(C)C

InChI Key InChIKey=FIOMEQRTYJXCGL-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 429656   

TargetNuclear receptor subfamily 1 group I member 2(Human)
St. Jude Children''S Research Hospital

US Patent
LigandPNGBDBM429656(US10550091, No. LC-65 | US10947203, No. LC-65)
Affinity DataIC50: 1.10E+3nMAssay Description:The time-resolved fluorescence resonance transfer (TR-FRET) hPXR competitive binding assay was performed according to the manufacturer's instruct...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
Go to US Patent

TargetNuclear receptor subfamily 1 group I member 2(Human)
St. Jude Children''S Research Hospital

US Patent
LigandPNGBDBM429656(US10550091, No. LC-65 | US10947203, No. LC-65)
Affinity DataEC50:  6.10E+3nMAssay Description:The hPXR transactivation assays (PXR agonistic and antagonistic assays) were performed in the HepG2 cells stably expressing FLAG-hPXR and CYP3A4-luci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
Go to US Patent

TargetNuclear receptor subfamily 1 group I member 2(Human)
St. Jude Children''S Research Hospital

US Patent
LigandPNGBDBM429656(US10550091, No. LC-65 | US10947203, No. LC-65)
Affinity DataIC50: 1.10E+3nMAssay Description:The time-resolved fluorescence resonance transfer (TR-FRET) hPXR competitive binding assay was performed according to the manufacturer's instruct...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
Go to US Patent

TargetNuclear receptor subfamily 1 group I member 2(Human)
St. Jude Children''S Research Hospital

US Patent
LigandPNGBDBM429656(US10550091, No. LC-65 | US10947203, No. LC-65)
Affinity DataEC50:  6.10E+3nMAssay Description:The hPXR transactivation assays (PXR agonistic and antagonistic assays) were performed in the HepG2 cells stably expressing FLAG-hPXR and CYP3A4-luci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
Go to US Patent