BDBM429564 US10550089, Example 38::US10995072, Example 38

SMILES CC(C)c1ccc2c(F)ccc(C(O)c3ncc[nH]3)n12

InChI Key InChIKey=WOTQTJNQQFIOAP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 429564   

TargetProteinase-activated receptor 2(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM429564(US10550089, Example 38 | US10995072, Example 38)
Affinity DataIC50: 1.91E+3nMAssay Description:Inositol monophosphate (IP1) production were measured in 1321N1 cells stably expressing human PAR2 using an IP-One HTRF assay kit (Cisbio). 80 nl of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
Go to US Patent

TargetProteinase-activated receptor 2(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM429564(US10550089, Example 38 | US10995072, Example 38)
Affinity DataIC50: 1.39E+4nMAssay Description:Calcium mobilization was measured using 1321N1 cells stably expressing human PAR2. Cells were seeded in 384-well plates at 4,000 cells per well in 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
Go to US Patent

TargetProteinase-activated receptor 2(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM429564(US10550089, Example 38 | US10995072, Example 38)
Affinity DataIC50: 1.91E+3nMAssay Description:Inositol monophosphate (IP1) production were measured in 1321N1 cells stably expressing human PAR2 using an IP-One HTRF assay kit (Cisbio). 80 nl of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2021
Entry Details
Go to US Patent

TargetProteinase-activated receptor 2(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM429564(US10550089, Example 38 | US10995072, Example 38)
Affinity DataIC50: 1.39E+4nMAssay Description:Calcium mobilization was measured using 1321N1 cells stably expressing human PAR2. Cells were seeded in 384-well plates at 4,000 cells per well in 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2021
Entry Details
Go to US Patent