BDBM429447 6-(5- (cyclopropylcarbamoyl)- 3-fluoro-2- methylphenyl)-N- neopentylpyridazin-3- carboxamide::US10550073, Example 59

SMILES Cc1c(F)cc(cc1-c1ccc(nn1)C(=O)NCC(C)(C)C)C(=O)NC1CC1

InChI Key InChIKey=OPUVLNNWYOSGSU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 429447   

TargetMitogen-activated protein kinase 14(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandPNGBDBM429447(6-(5- (cyclopropylcarbamoyl)- 3-fluoro-2- methylph...)
Affinity DataIC50: 100nMAssay Description:Experimental Method: 40 nM p38a was added into a reaction buffer, which include 20 mM HEPES (4-hydroxyethylpiperazine ethanesulfonic acid), 5 mM MgCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
Go to US Patent

TargetCytochrome P450 2C9(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandPNGBDBM429447(6-(5- (cyclopropylcarbamoyl)- 3-fluoro-2- methylph...)
Affinity DataIC50: 5.00E+4nMAssay Description:Experimental Method: 4-hydroxydiclofenac (the substrate for CYP450 and 2C9 enzymes) and different doses of compounds were added into human liver micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
Go to US Patent