BDBM429092 US10533010, Example I-190::US11208415, Example I-190

SMILES Cc1nn(CCN2CCOCC2)c(C)c1-c1c(Cl)ccc2c(CCCOc3cc(C)c(Cl)c(C)c3)c([nH]c12)C(=O)Nc1ccc(cc1)C(O)=O

InChI Key InChIKey=RHXXXTCCWGZJON-UHFFFAOYSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 429092   

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Vanderbilt University

US Patent
LigandPNGBDBM429092(US10533010, Example I-190 | US11208415, Example I-...)
Affinity DataKi: <7nMAssay Description:Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Vanderbilt University

US Patent
LigandPNGBDBM429092(US10533010, Example I-190 | US11208415, Example I-...)
Affinity DataKi: <7nMAssay Description:Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2022
Entry Details
Go to US Patent

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Vanderbilt University

US Patent
LigandPNGBDBM429092(US10533010, Example I-190 | US11208415, Example I-...)
Affinity DataKi: <50nMAssay Description:Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Vanderbilt University

US Patent
LigandPNGBDBM429092(US10533010, Example I-190 | US11208415, Example I-...)
Affinity DataKi: <50nMAssay Description:Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2022
Entry Details
Go to US Patent

TargetApoptosis regulator Bcl-2(Human)
Vanderbilt University

US Patent
LigandPNGBDBM429092(US10533010, Example I-190 | US11208415, Example I-...)
Affinity DataKi:  1.64E+3nMAssay Description:Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

TargetApoptosis regulator Bcl-2(Human)
Vanderbilt University

US Patent
LigandPNGBDBM429092(US10533010, Example I-190 | US11208415, Example I-...)
Affinity DataKi:  1.64E+3nMAssay Description:Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2022
Entry Details
Go to US Patent

TargetBcl-2-like protein 1(Human)
Vanderbilt University

US Patent
LigandPNGBDBM429092(US10533010, Example I-190 | US11208415, Example I-...)
Affinity DataKi:  4.56E+4nMAssay Description:Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

TargetBcl-2-like protein 1(Human)
Vanderbilt University

US Patent
LigandPNGBDBM429092(US10533010, Example I-190 | US11208415, Example I-...)
Affinity DataKi:  4.56E+4nMAssay Description:Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2022
Entry Details
Go to US Patent