BDBM428870 US10533010, Example I-66::US11208415, Example I-66

SMILES Cc1nn(C)c(C)c1-c1cccc2c(CCCOc3cc(C)c(Cl)c(C)c3)c(C(=O)NCc3ccc(o3)C(O)=O)n(C)c12

InChI Key InChIKey=ABPQSQFYCNXMGD-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 428870   

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Vanderbilt University

US Patent
LigandPNGBDBM428870(US10533010, Example I-66 | US11208415, Example I-6...)
Affinity DataKi: <50nMAssay Description:Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Vanderbilt University

US Patent
LigandPNGBDBM428870(US10533010, Example I-66 | US11208415, Example I-6...)
Affinity DataKi: <50nMAssay Description:Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Vanderbilt University

US Patent
LigandPNGBDBM428870(US10533010, Example I-66 | US11208415, Example I-6...)
Affinity DataKi: <50nMAssay Description:Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2022
Entry Details
Go to US Patent

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Vanderbilt University

US Patent
LigandPNGBDBM428870(US10533010, Example I-66 | US11208415, Example I-6...)
Affinity DataKi: <50nMAssay Description:Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2022
Entry Details
Go to US Patent