BDBM427879 US10544143, Example 313::US10544143, Example 320::US10730877, Example 320::US11053244, Example 320

SMILES CCN(C)C1CCC(CC1)c1nc2c(C(C)C)c([nH]c2cc1C)-c1cc(OC)c2ncnn2c1

InChI Key InChIKey=UUNSBEYOEIRBHS-UHFFFAOYSA-N

Data  18 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 427879   

TargetToll-like receptor 7(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM427879(US10544143, Example 313 | US10544143, Example 320 ...)
Affinity DataIC50: 1nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
Go to US Patent

TargetToll-like receptor 9(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM427879(US10544143, Example 313 | US10544143, Example 320 ...)
Affinity DataIC50: 1.48E+3nMAssay Description:HEK-Blue -cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
Go to US Patent

TargetToll-like receptor 8(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM427879(US10544143, Example 313 | US10544143, Example 320 ...)
Affinity DataIC50: 22nMAssay Description:HEK-Blue -cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
Go to US Patent

TargetToll-like receptor 7(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM427879(US10544143, Example 313 | US10544143, Example 320 ...)
Affinity DataIC50: 1nMAssay Description:HEK-Blue -cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
Go to US Patent

TargetToll-like receptor 9(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM427879(US10544143, Example 313 | US10544143, Example 320 ...)
Affinity DataIC50: 1.20E+3nMAssay Description:HEK-Blue -cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
Go to US Patent

TargetToll-like receptor 8(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM427879(US10544143, Example 313 | US10544143, Example 320 ...)
Affinity DataIC50: 7nMAssay Description:HEK-Blue -cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
Go to US Patent

TargetToll-like receptor 7(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM427879(US10544143, Example 313 | US10544143, Example 320 ...)
Affinity DataIC50: 0.210nMAssay Description:HEK-Blue -cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
Go to US Patent

TargetToll-like receptor 9(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM427879(US10544143, Example 313 | US10544143, Example 320 ...)
Affinity DataIC50: 1.48E+3nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
Go to US Patent

TargetToll-like receptor 8(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM427879(US10544143, Example 313 | US10544143, Example 320 ...)
Affinity DataIC50: 22nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
Go to US Patent

TargetToll-like receptor 7(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM427879(US10544143, Example 313 | US10544143, Example 320 ...)
Affinity DataIC50: 0.210nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

TargetToll-like receptor 9(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM427879(US10544143, Example 313 | US10544143, Example 320 ...)
Affinity DataIC50: 1.20E+3nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
Go to US Patent

TargetToll-like receptor 8(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM427879(US10544143, Example 313 | US10544143, Example 320 ...)
Affinity DataIC50: 7nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
Go to US Patent

TargetToll-like receptor 7(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM427879(US10544143, Example 313 | US10544143, Example 320 ...)
Affinity DataIC50: 0.210nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
Go to US Patent

TargetToll-like receptor 9(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM427879(US10544143, Example 313 | US10544143, Example 320 ...)
Affinity DataIC50: 1.48E+3nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

TargetToll-like receptor 8(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM427879(US10544143, Example 313 | US10544143, Example 320 ...)
Affinity DataIC50: 22nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

TargetToll-like receptor 7(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM427879(US10544143, Example 313 | US10544143, Example 320 ...)
Affinity DataIC50: 1nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

TargetToll-like receptor 9(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM427879(US10544143, Example 313 | US10544143, Example 320 ...)
Affinity DataIC50: 1.20E+3nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

TargetToll-like receptor 8(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM427879(US10544143, Example 313 | US10544143, Example 320 ...)
Affinity DataIC50: 7nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent