BDBM427139 (3R)-2-[(4-chloro-2-methanesulfonylphenyl)methyl]-3-(4-chlorophenyl)-4-fluoro-6-[hydroxy(oxan-4-yl)methyl]-3-{[1-(hydroxymethyl)cyclopropyl]methoxy}-2,3-dihydro-1H-isoindol-1-one::US10544132, Example 84::US10981898, Example 83

SMILES CS(=O)(=O)c1cc(Cl)ccc1CN1C(=O)c2cc(cc(F)c2[C@]1(OCC1(CO)CC1)c1ccc(Cl)cc1)[C@H](O)C1CCOCC1

InChI Key InChIKey=IRIZYNABKNVLML-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 427139   

LigandPNGBDBM427139((3R)-2-[(4-chloro-2-methanesulfonylphenyl)methyl]-...)
Affinity DataIC50: 1nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM427139((3R)-2-[(4-chloro-2-methanesulfonylphenyl)methyl]-...)
Affinity DataIC50: 3.90E+4nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent