BDBM426563 2-fluoro-4-[3-(6-fluoro-1-propan-2- ylbenzimidazol-5-yl)-6-[4- (methylamino)piperidin-1- yl]pyrazin-2-yl]benzonitrile::US10543198, Example 67::US10864202, Example 67

SMILES CNC1CCN(CC1)c1cnc(-c2cc3ncn(C(C)C)c3cc2F)c(n1)-c1ccc(C#N)c(F)c1

InChI Key InChIKey=KIYRZZKEMDPTIV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 426563   

TargetLysine-specific histone demethylase 1A(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM426563(US10543198, Example 67 | 2-fluoro-4-[3-(6-fluoro-1...)
Affinity DataIC50: 100nMAssay Description:The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2021
Entry Details
US Patent

TargetLysine-specific histone demethylase 1A(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM426563(US10543198, Example 67 | 2-fluoro-4-[3-(6-fluoro-1...)
Affinity DataIC50: 100nMAssay Description:This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2020
Entry Details
US Patent