BDBM426560 2-fluoro-4-[3-[2-(1- hydroxycyclopentyl)ethynyl]-6-[4- (methylamino)piperidin-1- yl]pyrazin-2-yl]benzonitrile::US10543198, Example 64::US10864202, Example 64

SMILES CNC1CCN(CC1)c1cnc(C#CC2(O)CCCC2)c(n1)-c1ccc(C#N)c(F)c1

InChI Key InChIKey=JJQDSQGNBFMJJH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 426560   

TargetLysine-specific histone demethylase 1A(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM426560(US10543198, Example 64 | 2-fluoro-4-[3-[2-(1- hydr...)
Affinity DataIC50: 100nMAssay Description:This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2020
Entry Details
US Patent

TargetLysine-specific histone demethylase 1A(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM426560(US10543198, Example 64 | 2-fluoro-4-[3-[2-(1- hydr...)
Affinity DataIC50: 100nMAssay Description:The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2021
Entry Details
US Patent