BDBM426495 US10543199, Compound 45::US10543199, Compound 58::US10543199, Compound 72::US10543199, Compound 76::US10543199, Compound 83::US10780082, Compound 83

SMILES CC1Oc2cc(cnc2N)-c2c(CN(C)C(=O)c3ccc(F)cc13)nn(C)c2C#N

InChI Key InChIKey=IIXWYSCJSQVBQM-UHFFFAOYSA-N

Data  25 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 426495   

TargetALK tyrosine kinase receptor(Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM426495(US10543199, Compound 45 | US10543199, Compound 76 ...)
Affinity DataIC50: 1nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2021
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor(Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM426495(US10543199, Compound 45 | US10543199, Compound 76 ...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of ALK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetALK tyrosine kinase receptor [L1196M](Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM426495(US10543199, Compound 45 | US10543199, Compound 76 ...)
Affinity DataIC50: 55nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2020
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor(Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM426495(US10543199, Compound 45 | US10543199, Compound 76 ...)
Affinity DataIC50: 1nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2020
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor [L1196M](Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM426495(US10543199, Compound 45 | US10543199, Compound 76 ...)
Affinity DataIC50: 55nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2020
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor(Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM426495(US10543199, Compound 45 | US10543199, Compound 76 ...)
Affinity DataIC50: 1nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2020
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor [L1196M](Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM426495(US10543199, Compound 45 | US10543199, Compound 76 ...)
Affinity DataIC50: 55nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2020
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor(Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM426495(US10543199, Compound 45 | US10543199, Compound 76 ...)
Affinity DataIC50: 1nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2020
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor [L1196M](Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM426495(US10543199, Compound 45 | US10543199, Compound 76 ...)
Affinity DataIC50: 55nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2020
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor(Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM426495(US10543199, Compound 45 | US10543199, Compound 76 ...)
Affinity DataIC50: 1nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2020
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor [L1196M](Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM426495(US10543199, Compound 45 | US10543199, Compound 76 ...)
Affinity DataIC50: 55nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2020
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor(Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM426495(US10543199, Compound 45 | US10543199, Compound 76 ...)
Affinity DataIC50: 1nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2020
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor [L1196M](Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM426495(US10543199, Compound 45 | US10543199, Compound 76 ...)
Affinity DataIC50: 55nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2021
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor(Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM426495(US10543199, Compound 45 | US10543199, Compound 76 ...)
Affinity DataIC50: 1nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2021
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor [L1196M](Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM426495(US10543199, Compound 45 | US10543199, Compound 76 ...)
Affinity DataIC50: 55nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2021
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor(Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM426495(US10543199, Compound 45 | US10543199, Compound 76 ...)
Affinity DataIC50: 1nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2021
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor [L1196M](Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM426495(US10543199, Compound 45 | US10543199, Compound 76 ...)
Affinity DataIC50: 55nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2021
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor(Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM426495(US10543199, Compound 45 | US10543199, Compound 76 ...)
Affinity DataIC50: 1nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2021
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor [L1196M](Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM426495(US10543199, Compound 45 | US10543199, Compound 76 ...)
Affinity DataIC50: 55nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2021
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor(Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM426495(US10543199, Compound 45 | US10543199, Compound 76 ...)
Affinity DataIC50: 1nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2021
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor [L1196M](Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM426495(US10543199, Compound 45 | US10543199, Compound 76 ...)
Affinity DataIC50: 55nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2021
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor(Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM426495(US10543199, Compound 45 | US10543199, Compound 76 ...)
Affinity DataIC50: 1nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2021
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor [L1196M](Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM426495(US10543199, Compound 45 | US10543199, Compound 76 ...)
Affinity DataIC50: 55nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2021
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor(Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM426495(US10543199, Compound 45 | US10543199, Compound 76 ...)
Affinity DataIC50: 1nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2021
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor [L1196M](Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM426495(US10543199, Compound 45 | US10543199, Compound 76 ...)
Affinity DataIC50: 5.5nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2021
Entry Details
Go to US Patent