BDBM426445 (2-(2,2- difluoroethoxy)pyridin- 3-yl)((2R,5R)-2-methyl-5-((3- (trifluoromethyl)imidazo [1,2-alpha]pyrazin-8- yl)oxy)piperidin-1- yl)methanone::US10526336, Example 64

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1cccnc1OCC(F)F)Oc1nccn2c(cnc12)C(F)(F)F

InChI Key InChIKey=RRBUYFQLRRJGAX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 426445   

TargetOrexin receptor type 2(Human)
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426445(US10526336, Example 64 | (2-(2,2- difluoroethoxy)p...)
Affinity DataIC50: 17.4nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426445(US10526336, Example 64 | (2-(2,2- difluoroethoxy)p...)
Affinity DataIC50: 1.00E+4nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2020
Entry Details
US Patent