BDBM426367 US10526325, Compound A43

SMILES C[C@@](O)(C(=O)N1CCc2ncn(c2C1)-c1ccccc1)C(F)(F)F

InChI Key InChIKey=MQVUJKAMFVVGJN-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 426367   

LigandPNGBDBM426367(US10526325, Compound A43)
Affinity DataIC50: 1.65E+3nMAssay Description:ITC measurements were performed with a VP-ITC micro calorimeter. In general titrations were performed by titrating the protein (50 μM) to the te...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2020
Entry Details
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LigandPNGBDBM426367(US10526325, Compound A43)
Affinity DataKd: <300nMAssay Description:The biochemical activity assay for PDHK2 is based on the inactivation of PDC through phosphorylation by PDHK2. The assay is run in two steps: the enz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2020
Entry Details
Go to US Patent