BDBM426344 US10526325, Compound A20::US10829489, Compound A20::US11261185, Example 20

SMILES C[C@@H]1CN(Cc2cnn(c12)-c1ccc(F)cc1F)C(=O)[C@@](C)(O)C(F)(F)F

InChI Key InChIKey=IMEWHQKUSGQHMR-UHFFFAOYSA-N

Data  3 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 426344   

LigandPNGBDBM426344(US10526325, Compound A20 | US10829489, Compound A2...)
Affinity DataIC50: 300nMAssay Description:ITC measurements were performed with a VP-ITC micro calorimeter. In general titrations were performed by titrating the protein (50 μM) to the te...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2020
Entry Details
Go to US Patent

LigandPNGBDBM426344(US10526325, Compound A20 | US10829489, Compound A2...)
Affinity DataKd: <300nMAssay Description:The biochemical activity assay for PDHK2 is based on the inactivation of PDC through phosphorylation by PDHK2. The assay is run in two steps: the enz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2020
Entry Details
Go to US Patent

LigandPNGBDBM426344(US10526325, Compound A20 | US10829489, Compound A2...)
Affinity DataIC50: 300nMAssay Description:The PDC inactivation assay is performed in Greiner 384-well microtiter plates and is used for high throughput screen. 4 μl of PDHK2 (human, rec,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
Go to US Patent

LigandPNGBDBM426344(US10526325, Compound A20 | US10829489, Compound A2...)
Affinity DataKd: <300nMAssay Description:ITC measurements were performed with a VP-ITC micro calorimeter (Microcal, LLC/GE Healthcare Bio-Sciences AB, Uppsala, Sweden). In general titrations...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
Go to US Patent

LigandPNGBDBM426344(US10526325, Compound A20 | US10829489, Compound A2...)
Affinity DataIC50: 300nMAssay Description:The biochemical activity assay for PDHK2 is based on the inactivation of PDC through phosphorylation by PDHK2. The assay is run in two steps: the enz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2022
Entry Details
Go to US Patent