BDBM426327 US10526325, Compound A4::US10829489, Compound A4::US11261185, Example 44

SMILES C[C@@](O)(C(=O)N1CCc2c(C1)cnn2-c1ccc(F)cc1)C(F)(F)F

InChI Key InChIKey=NKXHIDRGRKPWLM-UHFFFAOYSA-N

Data  4 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 426327   

LigandPNGBDBM426327(US10526325, Compound A4 | US10829489, Compound A4 ...)
Affinity DataIC50: 300nMAssay Description:ITC measurements were performed with a VP-ITC micro calorimeter. In general titrations were performed by titrating the protein (50 μM) to the te...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2020
Entry Details
Go to US Patent

LigandPNGBDBM426327(US10526325, Compound A4 | US10829489, Compound A4 ...)
Affinity DataKd: <300nMAssay Description:The biochemical activity assay for PDHK2 is based on the inactivation of PDC through phosphorylation by PDHK2. The assay is run in two steps: the enz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2020
Entry Details
Go to US Patent

LigandPNGBDBM426327(US10526325, Compound A4 | US10829489, Compound A4 ...)
Affinity DataIC50: 300nMAssay Description:The PDC inactivation assay is performed in Greiner 384-well microtiter plates and is used for high throughput screen. 4 μl of PDHK2 (human, rec,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
Go to US Patent

LigandPNGBDBM426327(US10526325, Compound A4 | US10829489, Compound A4 ...)
Affinity DataKd: <300nMAssay Description:ITC measurements were performed with a VP-ITC micro calorimeter (Microcal, LLC/GE Healthcare Bio-Sciences AB, Uppsala, Sweden). In general titrations...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
Go to US Patent

LigandPNGBDBM426327(US10526325, Compound A4 | US10829489, Compound A4 ...)
Affinity DataIC50: 300nMAssay Description:The biochemical activity assay for PDHK2 is based on the inactivation of PDC through phosphorylation by PDHK2. The assay is run in two steps: the enz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2022
Entry Details
Go to US Patent

LigandPNGBDBM426327(US10526325, Compound A4 | US10829489, Compound A4 ...)
Affinity DataIC50: 1.65E+3nMAssay Description:The biochemical activity assay for PDHK2 is based on the inactivation of PDC through phosphorylation by PDHK2. The assay is run in two steps: the enz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2022
Entry Details
Go to US Patent