BDBM426224 5-[2-(4-Fluorophenyl)-7-morpholino-pyrazolo[1,5-c]pyrimidin-3-::US10513523, Example 164

SMILES Fc1ccc(cc1)-c1nn2c(nccc2c1-c1ccc2NC(=O)Cc2c1)N1CCOCC1

InChI Key InChIKey=YEBXPAZJAWFYJQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 426224   

TargetGlutamate receptor 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM426224(US10513523, Example 164 | 5-[2-(4-Fluorophenyl)-7-...)
Affinity DataIC50: 0.5nMAssay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
Go to US Patent

TargetGlutamate receptor 1/Voltage-dependent calcium channel gamma-2 subunit(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM426224(US10513523, Example 164 | 5-[2-(4-Fluorophenyl)-7-...)
Affinity DataIC50: 0.501nMAssay Description:Negative allosteric modulation of recombinant human GluA1 flop isoform/TARPgamma2 expressed in HEK293 cells assessed as inhibition of glutamate-induc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed