BDBM426144 4-[2-(4-Fluorophenyl)-8-morpholino-imidazo[1,2-a]pyrazin-3-yl]-phenol;::US10513523, Example 83

SMILES Oc1ccc(cc1)-c1c(nc2c(nccn12)N1CCOCC1)-c1ccc(F)cc1

InChI Key InChIKey=QWIRHDVUQFMGMP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 426144   

TargetGlutamate receptor 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM426144(US10513523, Example 83 | 4-[2-(4-Fluorophenyl)-8-m...)
Affinity DataIC50: 13nMAssay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
Go to US Patent

TargetGlutamate receptor 1/Voltage-dependent calcium channel gamma-2 subunit(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM426144(US10513523, Example 83 | 4-[2-(4-Fluorophenyl)-8-m...)
Affinity DataIC50: 13nMAssay Description:Negative allosteric modulation of recombinant human GluA1 flop isoform/TARPgamma2 expressed in HEK293 cells assessed as inhibition of glutamate-induc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetVoltage-dependent calcium channel gamma-8 subunit(Rat)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM426144(US10513523, Example 83 | 4-[2-(4-Fluorophenyl)-8-m...)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulation of TARPgamma8 in rat hippocampal neurons assessed as inhibition of glutamate-induced current at 10 uM at -60 mV holdin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed