BDBM426036 US10513518, Example 26::US10513518, Example 27

SMILES CC1=C(CCC1=O)N1CCC2(CCN(CC(O)c3ccc(cc3C)-n3cnnn3)CC2)C1=O

InChI Key InChIKey=MZIVXTBUCGFHNQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 426036   

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM426036(US10513518, Example 27 | US10513518, Example 26)
Affinity DataIC50: 87.1nMAssay Description:1. Seed HEK-hKir1.1 cells (50 μl at 20,000 cells/well) in 384-well PDL coated Microplates2. Allow cells to adhere overnight in humidified 37° C....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
Go to US Patent

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM426036(US10513518, Example 27 | US10513518, Example 26)
Affinity DataIC50: 74.5nMAssay Description:1. Seed HEK-hKir1.1 cells (50 μl at 20,000 cells/well) in 384-well PDL coated Microplates2. Allow cells to adhere overnight in humidified 37° C....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
Go to US Patent