BDBM425891 2-biphenyl-4-yl-N-hydroxy- 1-methyl-1H-benzimidazole- 5-carboxamide::US10512634, Example 225

SMILES Cn1c(nc2cc(ccc12)C(=O)NO)-c1ccc(cc1)-c1ccccc1

InChI Key InChIKey=XHZZHUQIJCWDGT-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 425891   

TargetHistone deacetylase 6(Human)
Kancera

US Patent
LigandPNGBDBM425891(2-biphenyl-4-yl-N-hydroxy- 1-methyl-1H-benzimidazo...)
Affinity DataIC50: 3.60nMAssay Description:All Examples were tested in HDAC1, 2, 3, 6 and 8 in vitro enzymatic assays. The assay principle is well known (Hauser et al. 2009, Bradner et al. 201...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
Kancera

US Patent
LigandPNGBDBM425891(2-biphenyl-4-yl-N-hydroxy- 1-methyl-1H-benzimidazo...)
Affinity DataIC50: 326nMAssay Description:All Examples were tested in HDAC1, 2, 3, 6 and 8 in vitro enzymatic assays. The assay principle is well known (Hauser et al. 2009, Bradner et al. 201...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
Go to US Patent

TargetHistone deacetylase 2(Human)
Kancera

US Patent
LigandPNGBDBM425891(2-biphenyl-4-yl-N-hydroxy- 1-methyl-1H-benzimidazo...)
Affinity DataIC50: 2.00E+5nMAssay Description:All Examples were tested in HDAC1, 2, 3, 6 and 8 in vitro enzymatic assays. The assay principle is well known (Hauser et al. 2009, Bradner et al. 201...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
Go to US Patent

TargetHistone deacetylase 3(Human)
Kancera

US Patent
LigandPNGBDBM425891(2-biphenyl-4-yl-N-hydroxy- 1-methyl-1H-benzimidazo...)
Affinity DataIC50: 2.00E+5nMAssay Description:All Examples were tested in HDAC1, 2, 3, 6 and 8 in vitro enzymatic assays. The assay principle is well known (Hauser et al. 2009, Bradner et al. 201...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
Go to US Patent

TargetHistone deacetylase 6(Human)
Kancera

US Patent
LigandPNGBDBM425891(2-biphenyl-4-yl-N-hydroxy- 1-methyl-1H-benzimidazo...)
Affinity DataIC50: 3.60nMAssay Description:All Examples were tested in HDAC1, 2, 3, 6 and 8 in vitro enzymatic assays. The assay principle is well known (Hauser et al. 2009, Bradner et al. 201...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
Go to US Patent

TargetHistone deacetylase 8(Human)
Kancera

US Patent
LigandPNGBDBM425891(2-biphenyl-4-yl-N-hydroxy- 1-methyl-1H-benzimidazo...)
Affinity DataIC50: 74nMAssay Description:All Examples were tested in HDAC1, 2, 3, 6 and 8 in vitro enzymatic assays. The assay principle is well known (Hauser et al. 2009, Bradner et al. 201...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
Go to US Patent