BDBM425867 2-(4-ethylphenyl)-N-hydroxy- 1H-benzimidazole-6- carboxamide::US10512634, Example 109

SMILES CCc1ccc(cc1)-c1nc2ccc(cc2[nH]1)C(=O)NO

InChI Key InChIKey=YQHCRDNLHGZOFE-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 425867   

TargetHistone deacetylase 6(Human)
Kancera

US Patent
LigandPNGBDBM425867(2-(4-ethylphenyl)-N-hydroxy- 1H-benzimidazole-6- c...)
Affinity DataIC50: 46nMAssay Description:All Examples were tested in HDAC1, 2, 3, 6 and 8 in vitro enzymatic assays. The assay principle is well known (Hauser et al. 2009, Bradner et al. 201...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
Kancera

US Patent
LigandPNGBDBM425867(2-(4-ethylphenyl)-N-hydroxy- 1H-benzimidazole-6- c...)
Affinity DataIC50: 6.50E+3nMAssay Description:All Examples were tested in HDAC1, 2, 3, 6 and 8 in vitro enzymatic assays. The assay principle is well known (Hauser et al. 2009, Bradner et al. 201...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
Go to US Patent

TargetHistone deacetylase 2(Human)
Kancera

US Patent
LigandPNGBDBM425867(2-(4-ethylphenyl)-N-hydroxy- 1H-benzimidazole-6- c...)
Affinity DataIC50: 1.65E+5nMAssay Description:All Examples were tested in HDAC1, 2, 3, 6 and 8 in vitro enzymatic assays. The assay principle is well known (Hauser et al. 2009, Bradner et al. 201...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
Go to US Patent

TargetHistone deacetylase 3(Human)
Kancera

US Patent
LigandPNGBDBM425867(2-(4-ethylphenyl)-N-hydroxy- 1H-benzimidazole-6- c...)
Affinity DataIC50: 2.20E+3nMAssay Description:All Examples were tested in HDAC1, 2, 3, 6 and 8 in vitro enzymatic assays. The assay principle is well known (Hauser et al. 2009, Bradner et al. 201...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
Go to US Patent

TargetHistone deacetylase 6(Human)
Kancera

US Patent
LigandPNGBDBM425867(2-(4-ethylphenyl)-N-hydroxy- 1H-benzimidazole-6- c...)
Affinity DataIC50: 46nMAssay Description:All Examples were tested in HDAC1, 2, 3, 6 and 8 in vitro enzymatic assays. The assay principle is well known (Hauser et al. 2009, Bradner et al. 201...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
Go to US Patent

TargetHistone deacetylase 8(Human)
Kancera

US Patent
LigandPNGBDBM425867(2-(4-ethylphenyl)-N-hydroxy- 1H-benzimidazole-6- c...)
Affinity DataIC50: 1.20E+3nMAssay Description:All Examples were tested in HDAC1, 2, 3, 6 and 8 in vitro enzymatic assays. The assay principle is well known (Hauser et al. 2009, Bradner et al. 201...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
Go to US Patent