BDBM425865 N-hydroxy-2-thiophen-2-yl- 1H-benzimidazole-6- carboxamide::US10512634, Example 98

SMILES ONC(=O)c1ccc2nc([nH]c2c1)-c1cccs1

InChI Key InChIKey=GLABLFHFXZJGCS-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 425865   

TargetHistone deacetylase 6(Human)
Kancera

US Patent
LigandPNGBDBM425865(N-hydroxy-2-thiophen-2-yl- 1H-benzimidazole-6- car...)
Affinity DataIC50: 7nMAssay Description:All Examples were tested in HDAC1, 2, 3, 6 and 8 in vitro enzymatic assays. The assay principle is well known (Hauser et al. 2009, Bradner et al. 201...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
Kancera

US Patent
LigandPNGBDBM425865(N-hydroxy-2-thiophen-2-yl- 1H-benzimidazole-6- car...)
Affinity DataIC50: 4.40E+3nMAssay Description:All Examples were tested in HDAC1, 2, 3, 6 and 8 in vitro enzymatic assays. The assay principle is well known (Hauser et al. 2009, Bradner et al. 201...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
Go to US Patent

TargetHistone deacetylase 2(Human)
Kancera

US Patent
LigandPNGBDBM425865(N-hydroxy-2-thiophen-2-yl- 1H-benzimidazole-6- car...)
Affinity DataIC50: 2.40E+4nMAssay Description:All Examples were tested in HDAC1, 2, 3, 6 and 8 in vitro enzymatic assays. The assay principle is well known (Hauser et al. 2009, Bradner et al. 201...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
Go to US Patent

TargetHistone deacetylase 3(Human)
Kancera

US Patent
LigandPNGBDBM425865(N-hydroxy-2-thiophen-2-yl- 1H-benzimidazole-6- car...)
Affinity DataIC50: 1.90E+3nMAssay Description:All Examples were tested in HDAC1, 2, 3, 6 and 8 in vitro enzymatic assays. The assay principle is well known (Hauser et al. 2009, Bradner et al. 201...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
Go to US Patent

TargetHistone deacetylase 6(Human)
Kancera

US Patent
LigandPNGBDBM425865(N-hydroxy-2-thiophen-2-yl- 1H-benzimidazole-6- car...)
Affinity DataIC50: 7nMAssay Description:All Examples were tested in HDAC1, 2, 3, 6 and 8 in vitro enzymatic assays. The assay principle is well known (Hauser et al. 2009, Bradner et al. 201...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
Go to US Patent

TargetHistone deacetylase 8(Human)
Kancera

US Patent
LigandPNGBDBM425865(N-hydroxy-2-thiophen-2-yl- 1H-benzimidazole-6- car...)
Affinity DataIC50: 290nMAssay Description:All Examples were tested in HDAC1, 2, 3, 6 and 8 in vitro enzymatic assays. The assay principle is well known (Hauser et al. 2009, Bradner et al. 201...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
Go to US Patent