BDBM425864 N-hydroxy-2-[4-(1- methylethoxy)phenyl]-1H- benzimidazole-6-carboxamide::US10512634, Example 97

SMILES CC(C)Oc1ccc(cc1)-c1nc2ccc(cc2[nH]1)C(=O)NO

InChI Key InChIKey=KFSYULNTFILPPX-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 425864   

TargetHistone deacetylase 6(Human)
Kancera

US Patent
LigandPNGBDBM425864(N-hydroxy-2-[4-(1- methylethoxy)phenyl]-1H- benzim...)
Affinity DataIC50: 12nMAssay Description:All Examples were tested in HDAC1, 2, 3, 6 and 8 in vitro enzymatic assays. The assay principle is well known (Hauser et al. 2009, Bradner et al. 201...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
Kancera

US Patent
LigandPNGBDBM425864(N-hydroxy-2-[4-(1- methylethoxy)phenyl]-1H- benzim...)
Affinity DataIC50: 5.70E+3nMAssay Description:All Examples were tested in HDAC1, 2, 3, 6 and 8 in vitro enzymatic assays. The assay principle is well known (Hauser et al. 2009, Bradner et al. 201...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
Go to US Patent

TargetHistone deacetylase 2(Human)
Kancera

US Patent
LigandPNGBDBM425864(N-hydroxy-2-[4-(1- methylethoxy)phenyl]-1H- benzim...)
Affinity DataIC50: 3.30E+4nMAssay Description:All Examples were tested in HDAC1, 2, 3, 6 and 8 in vitro enzymatic assays. The assay principle is well known (Hauser et al. 2009, Bradner et al. 201...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
Go to US Patent

TargetHistone deacetylase 3(Human)
Kancera

US Patent
LigandPNGBDBM425864(N-hydroxy-2-[4-(1- methylethoxy)phenyl]-1H- benzim...)
Affinity DataIC50: 2.40E+3nMAssay Description:All Examples were tested in HDAC1, 2, 3, 6 and 8 in vitro enzymatic assays. The assay principle is well known (Hauser et al. 2009, Bradner et al. 201...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
Go to US Patent

TargetHistone deacetylase 6(Human)
Kancera

US Patent
LigandPNGBDBM425864(N-hydroxy-2-[4-(1- methylethoxy)phenyl]-1H- benzim...)
Affinity DataIC50: 12nMAssay Description:All Examples were tested in HDAC1, 2, 3, 6 and 8 in vitro enzymatic assays. The assay principle is well known (Hauser et al. 2009, Bradner et al. 201...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
Go to US Patent

TargetHistone deacetylase 8(Human)
Kancera

US Patent
LigandPNGBDBM425864(N-hydroxy-2-[4-(1- methylethoxy)phenyl]-1H- benzim...)
Affinity DataIC50: 260nMAssay Description:All Examples were tested in HDAC1, 2, 3, 6 and 8 in vitro enzymatic assays. The assay principle is well known (Hauser et al. 2009, Bradner et al. 201...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
Go to US Patent